Description

2-Bromo-4-(tert-Butyl-D9)-Pyridine is a deuterium-labeled pyridine derivative, a crucial building block for advanced research and development. This compound is specifically valued for its role as a stable isotope-labeled internal standard in analytical chemistry, enabling precise quantification and metabolic studies. It is primarily sought after by pharmaceutical researchers, agrochemical developers, and analytical laboratories engaged in method development, pharmacokinetics, and environmental fate studies using mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for drug and metabolite analysis.
• Pharmaceutical Research: Serves as a deuterated intermediate in the synthesis of isotopically labeled drug candidates for metabolism and pharmacokinetic (DMPK) studies.
• Agrochemical Development: Employed in the synthesis of labeled pesticide analogs to study degradation pathways and environmental residue analysis.
• Metabolomics & Biomarker Discovery: Facilitates accurate profiling of small molecules in complex biological samples.
• Chemical Biology Probes: Used to create tagged molecular tools for investigating biological mechanisms and protein interactions.
• Regulatory Compliance Testing: Supports analytical methods required for FDA, EMA, and other regulatory agency submissions.

Basic Information

Product Name	2-Bromo-4-(tert-Butyl-D9)-Pyridine
CAS No.	1643543-24-1
Molecular Formula	C9H2D9BrN
Molecular Weight	216.13 g/mol (for deuterated form)
Synonyms	4-(tert-Butyl-d9)-2-bromopyridine; 2-Bromo-4-(1,1-dimethylethyl-d9)pyridine; 2-Bromo-4-(tert-butyl-d9)pyridine; Deutero-labeled 2-Bromo-4-tert-butylpyridine; 2-Bromo-4-(tert-butyl-2H9)pyridine; 2-Bromo-4-(t-butyl-d9)pyridine; Perdeuterated tert-butyl bromopyridine derivative; (Pyridine-4-(2H9)-tert-butyl)-2-bromo
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(tert-Butyl-D9)-Pyridine is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, critical for its use as an analytical standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-content), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.