Description

n-Boc-1H-Indole-4-Methanamine,n-(4-Fluoro-2-Methylphenyl)-2-Methyl- is a high-purity, advanced pharmaceutical intermediate featuring a protected indole scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying biological processes and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	n-Boc-1H-Indole-4-Methanamine,n-(4-Fluoro-2-Methylphenyl)-2-Methyl-
CAS No.	1642555-01-8
Molecular Formula	C22H25FN2O2
Molecular Weight	368.45 g/mol
Synonyms	1H-Indole-4-methanamine, N-[(1,1-dimethylethoxy)carbonyl]-N-[2-methyl-4-fluorophenyl]-2-methyl-; tert-Butyl N-[4-(aminomethyl)-1H-indol-1-yl]-N-(4-fluoro-2-methylphenyl)carbamate; 1-Boc-4-(aminomethyl)indole derivative; N-Boc-N-(4-fluoro-2-methylphenyl)-2-methyl-1H-indole-4-methanamine; Advanced Indole Intermediate 1642555-01-8
EINECS	Contact for details

Quality Control

Our n-Boc-1H-Indole-4-Methanamine,n-(4-Fluoro-2-Methylphenyl)-2-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all critical quality attributes. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.