Description

Oclacitinib Maleate CAS NO 1640292-55-2 is a selective Janus kinase (JAK) inhibitor, specifically formulated as the maleate salt to enhance stability and bioavailability. This active pharmaceutical ingredient (API) is critical for developing targeted therapeutics that modulate immune and inflammatory responses. It is primarily required by pharmaceutical manufacturers and veterinary pharmaceutical companies engaged in the research, development, and production of treatments for allergic dermatitis and pruritus in animals.

Application

• Veterinary Pharmaceutical API: Primary active ingredient in prescription medications for controlling pruritus (itch) associated with allergic dermatitis and atopic dermatitis in dogs.
• Drug Substance Manufacturing: Serves as the key drug substance for the commercial-scale production of finished dosage forms, such as chewable tablets.
• Veterinary Research & Development: Used in preclinical and clinical studies for developing new therapeutic applications in veterinary medicine.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Comparative Bioavailability Studies: Utilized in the development and testing of generic veterinary pharmaceutical products.
• Pharmacological Research: A tool compound for investigating JAK-STAT signaling pathways in immunological research models.

Basic Information

Product Name	Oclacitinib Maleate
CAS No.	1640292-55-2
Molecular Formula	C22H25N5O6
Molecular Weight	455.47 g/mol
Synonyms	Oclacitinib hydrogen maleate; PF-03394197 (maleate); (3S)-3-[5-[(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino]-2H-pyrazolo[3,4-c]pyridin-2-yl]-3-cyclopentylpropanoic acid compound with (2Z)-but-2-enedioic acid; Apoquel® API (Veterinary); CP-690,550-10; Janus kinase inhibitor JAK1/JAK2
EINECS	Contact for details

Quality Control

Our Oclacitinib Maleate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for use as a pharmaceutical active ingredient. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C. Keep the container in a dry, well-ventilated area. Avoid exposure to excessive heat and moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.