Description

Deuterated Crosslinker Dsp-D8 CAS NO 1639836-65-9 is a deuterium-labeled analog of the homobifunctional NHS ester crosslinker, Dithiobis(succinimidyl propionate) (DSP). This compound is essential for advanced proteomics and structural biology research, enabling precise, stable-isotope labeling for mass spectrometry-based quantification and protein interaction studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotech companies specializing in drug discovery and biomarker identification.

Application

• Quantitative Proteomics: Used as a stable isotope-coded affinity tag for accurate, comparative protein quantification via mass spectrometry (MS).
• Protein-Protein Interaction Mapping: Facilitates the study of protein complexes and interaction networks through crosslinking mass spectrometry (XL-MS).
• Structural Biology: Aids in determining protein structures and conformational dynamics by providing distance constraints.
• Biomarker Discovery: Enables high-throughput screening and validation of disease-specific protein biomarkers.
• Drug Target Identification: Used to investigate drug-protein interactions and mechanisms of action.
• Deuterium-Labeled Internal Standards: Serves as a critical standard for absolute quantification in targeted proteomic assays.

Basic Information

Product Name	Deuterated Crosslinker Dsp-D8
CAS No.	1639836-65-9
Molecular Formula	C14D8H8N2O8S2
Molecular Weight	Contact for details
Synonyms	DSP-d8; Deuterated Dithiobis(succinimidyl propionate); D8-DSP; 3,3'-Dithiobis(propionic acid D2-N-succinimidyl ester); Dithiobis(succinimidyl D8-propionate); DTSP-d8; Lomant's Reagent-d8; DSP Crosslinker-d8
EINECS	Contact for details

Quality Control

Our Deuterated Crosslinker Dsp-D8 is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity are provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is moisture-sensitive and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Solubility	Soluble in DMF, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.