Description

(R)-n-(1-(1H-Indol-3-Yl)Propan-2-Yl)-2-Fluoro-2-Methylpropan-1-Amine is a high-purity chiral amine building block of significant interest in advanced pharmaceutical research and development. Its unique molecular architecture, featuring an indole moiety and a fluorinated alkyl chain, makes it a critical intermediate for synthesizing novel bioactive compounds. This product is essential for medicinal chemists and process development scientists working in pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and synthesis of potential new chemical entities (NCEs), particularly for central nervous system (CNS) and oncological targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel pharmacophores.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the production of active pharmaceutical ingredients (APIs) under GMP conditions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor in stereoselective synthesis to create enantiomerically pure compounds.
• Bioconjugation & Probe Development: Utilized in the development of biochemical probes and labeled compounds for diagnostic and research applications.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and development services for global clients.

Basic Information

Product Name	(R)-n-(1-(1H-Indol-3-Yl)Propan-2-Yl)-2-Fluoro-2-Methylpropan-1-Amine
CAS No.	1639042-36-6
Molecular Formula	C15H21FN2
Molecular Weight	248.34 g/mol
Synonyms	(R)-2-Fluoro-N-(1-(1H-indol-3-yl)propan-2-yl)-2-methylpropan-1-amine; (R)-1-(1H-Indol-3-yl)-N-(2-fluoro-2-methylpropyl)propan-2-amine; (R)-N-(1-(1H-Indol-3-yl)propan-2-yl)-2-fluoro-2-methylpropan-1-amine; (R)-Fluoro-methylpropanamine indole derivative; UNII-6H6R8S8K8F; 1639042-36-6; (R)-enantiomer of a fluorinated tryptamine analog
EINECS	Contact for details

Quality Control

Our (R)-n-(1-(1H-Indol-3-Yl)Propan-2-Yl)-2-Fluoro-2-Methylpropan-1-Amine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality guidelines and can provide material tailored to specific project requirements, including those for early-phase GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.