Description

2-[1-(Benzyloxy)-2-Methylpropan-2-Yl]-6-Fluoro-5-Nitro-1H-Indole CAS NO 1638771-94-4 is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole-based molecular structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the development of targeted therapies.

Application

This specialized indole derivative serves as a key building block in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with targeted biological activity.
• API Development: Integral to the synthetic route for developing complex Active Pharmaceutical Ingredients (APIs) that incorporate fluorinated and nitro-substituted indole scaffolds.
• Biochemical Tool Compound: May be utilized in biochemical assays and as a probe to study specific enzymatic pathways or receptor interactions in early-stage drug discovery.
• Custom Synthesis: Serves as a starting material or intermediate for custom synthesis projects undertaken by fine chemical manufacturers for client-specific molecule development.

Basic Information

Product Name	2-[1-(Benzyloxy)-2-Methylpropan-2-Yl]-6-Fluoro-5-Nitro-1H-Indole
CAS No.	1638771-94-4
Molecular Formula	C20H21FN2O3
Molecular Weight	356.40 g/mol
Synonyms	6-Fluoro-5-nitro-2-[1-(phenylmethoxy)-2-methyl-2-propanyl]-1H-indole; 2-(1-Benzyloxy-2-methylpropan-2-yl)-6-fluoro-5-nitro-1H-indole; 1H-Indole, 2-[1-(benzyloxy)-2-methyl-2-propanyl]-6-fluoro-5-nitro-; Benzyl 2-(6-fluoro-5-nitro-1H-indol-2-yl)-2-methylpropyl ether; 1638771-94-4
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for critical research applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as identity, purity, and impurity profiles. While produced under GMP-like conditions suitable for pharmaceutical development, specifications can be customized to meet the specific requirements of your research or process development phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.