Description

Methyl 5-Bromo-6-Fluoro-1H-Indole-3-Carboxylate is a high-purity, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its precise halogen substitution pattern, which enables targeted molecular modifications essential for developing novel active compounds. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for the synthesis of complex molecules, including potential drug candidates and specialized agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used in the creation of novel herbicides and fungicides, leveraging its halogenated indole core for enhanced bioactivity.
• Material Science Research: Serves as a precursor for functionalized organic materials, including organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects and contract research organizations (CROs) requiring specific halogenated indole scaffolds.

Basic Information

Product Name	Methyl 5-Bromo-6-Fluoro-1H-Indole-3-Carboxylate
CAS No.	1638759-63-3
Molecular Formula	C10H7BrFNO2
Molecular Weight	272.07 g/mol
Synonyms	5-Bromo-6-fluoro-1H-indole-3-carboxylic acid methyl ester; Methyl 5-bromo-6-fluoroindole-3-carboxylate; 5-Bromo-6-fluoroindole-3-carboxylic acid methyl ester; 1H-Indole-3-carboxylic acid, 5-bromo-6-fluoro-, methyl ester; 1638759-63-3; 5-Br-6-F-indole-3-COOMe
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Bromo-6-Fluoro-1H-Indole-3-Carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.