Description

(8Ar)-8A-Methyl-Octahydropyrrolo[1,2-A]Piperazine CAS NO 1638744-57-6 is a high-purity, advanced pharmaceutical intermediate belonging to the piperazine class of heterocyclic compounds. Its value lies in its role as a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules.
• API Development: Serves as a core structural scaffold for developing new chemical entities (NCEs) targeting neurological disorders.
• Antiviral Drug Research: Used in the research and development of novel antiviral compounds.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP manufacturing.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	(8Ar)-8A-Methyl-Octahydropyrrolo[1,2-A]Piperazine
CAS No.	1638744-57-6
Molecular Formula	C9H18N2
Molecular Weight	154.25 g/mol
Synonyms	(8aR)-8a-Methylhexahydro-1H-pyrrolo[1,2-a]piperazine; (8aR)-8a-Methyloctahydropyrrolo[1,2-a]piperazine; 8a-Methyloctahydropyrrolo[1,2-a]piperazine, (8aR)-; Pyrrolo[1,2-a]piperazine, octahydro-8a-methyl-, (8aR)-; (8aR)-8a-Methyloctahydro-1H-pyrrolo[1,2-a]piperazine
EINECS	Contact for details

Quality Control

Our (8Ar)-8A-Methyl-Octahydropyrrolo[1,2-A]Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.