Description

(1S,3R)-5-Bromo-3-({[tert-Butyl(Dimethyl)Silyl]Oxy}Methyl)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxyl group and a bromo-substituted tetrahydroisoquinoline core. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of complex bioactive molecules targeting neurological and oncological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential drug candidates, especially those with tetrahydroisoquinoline scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for developing new central nervous system (CNS) and oncology therapeutics.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying asymmetric synthesis, protective group chemistry, and heterocyclic compound reactivity.
• Custom Synthesis: A starting material for the custom synthesis of more complex, target-specific molecules for client-directed research projects.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	(1S,3R)-5-Bromo-3-({[tert-Butyl(Dimethyl)Silyl]Oxy}Methyl)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1638668-28-6
Molecular Formula	C₁₈H₂₉BrNO₂Si • HCl
Molecular Weight	435.88 g/mol (Free base: 399.42 g/mol)
Synonyms	5-Bromo-3-((tert-butyldimethylsilyloxy)methyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (1S,3R)-5-Bromo-1-methyl-3-(((tert-butyldimethylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline HCl; TBDMS-protected 5-bromo-1-methyl-1,2,3,4-tetrahydroisoquinolin-3-ylmethanol hydrochloride; 1638668-28-6; 5-Bromo-1-methyl-3-((TBDMS-oxy)methyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; (3R)-5-Bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl-1-methyl-1,2,3,4-tetrahydroisoquinoline monohydrochloride
EINECS	Contact for details

Quality Control

Our (1S,3R)-5-Bromo-3-({[tert-Butyl(Dimethyl)Silyl]Oxy}Methyl)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for sensitive pharmaceutical applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.