Description

(1S,3R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline is a sophisticated chiral building block and advanced pharmaceutical intermediate of significant interest in modern organic synthesis. Its value lies in its unique stereochemistry and functional groups, which enable the construction of complex molecular architectures with high precision. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Asymmetric Synthesis: Serves as a crucial precursor for constructing complex, enantiomerically pure tetrahydroisoquinoline scaffolds.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of target molecules under GMP conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein interactions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical services.

Basic Information

Product Name	(1S,3R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1638668-21-9
Molecular Formula	C₁₇H₂₈BrNOSi
Molecular Weight	370.40 g/mol
Synonyms	(1S,3R)-5-Bromo-3-(((tert-butyldimethylsilyl)oxy)methyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline; (1S,3R)-5-Bromo-1-methyl-3-((tert-butyldimethylsilyloxy)methyl)-1,2,3,4-tetrahydroisoquinoline; (1S,3R)-5-Bromo-3-((tert-butyldimethylsilyloxy)methyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline; 5-Bromo-3-(((tert-butyldimethylsilyl)oxy)methyl)-1-methyl-(1S,3R)-1,2,3,4-tetrahydroisoquinoline; TBDMS-protected bromo-tetrahydroisoquinoline derivative; (1S,3R)-5-Bromo-1-methyl-3-(TBDMS-oxymethyl)-1,2,3,4-tetrahydroisoquinoline; 1638668-21-9
EINECS	Contact for details

Quality Control

Our production of (1S,3R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure consistency and reliability. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and can be tailored to meet specific client requirements or regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.