Description

(R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-3,4-Dihydroisoquinoline is a high-purity, chiral synthetic intermediate of significant importance in modern pharmaceutical research and development. Its core value lies in its role as a key building block for constructing complex, biologically active molecules, particularly in the synthesis of potential drug candidates targeting the central nervous system. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical and biotechnology companies. The CAS number for this compound is provided in the table below.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel therapeutic agents, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Serves as a key starting material for scaling up the synthesis of active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in the construction of complex, enantiomerically pure isoquinoline-based scaffolds due to its defined (R)-configuration.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement.
• Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Item	Details
Product Name	(R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-3,4-Dihydroisoquinoline
CAS No.	1638668-20-8
Molecular Formula	C₁₇H₂₆BrNOSi
Molecular Weight	368.39 g/mol
Synonyms	(R)-5-Bromo-3-((tert-butyldimethylsilyloxy)methyl)-3,4-dihydroisoquinoline; (R)-5-Bromo-3-(((TBDMS)Oxy)Methyl)-3,4-Dihydroisoquinoline; (R)-5-Bromo-3-((TBDMSO)methyl)-1,2,3,4-tetrahydroisoquinoline; (R)-3-(((tert-Butyldimethylsilyl)oxy)methyl)-5-bromo-3,4-dihydroisoquinoline; TBDMS-protected (R)-5-bromo-3,4-dihydroisoquinoline methanol; (R)-5-Br-TBDMS-O-CH2-DHIQ
EINECS	Contact for details

Quality Control

Our (R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-3,4-Dihydroisoquinoline is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All batches are characterized by advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.