Description

(R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-1,2,3,4-Tetrahydroisoquinoline is a high-purity, chiral synthetic intermediate of significant importance in modern pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of complex bioactive molecules, particularly those targeting the central nervous system. It is primarily sought by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of potential therapeutic agents, especially in neuroscience and psychiatric drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in the construction of complex, enantiomerically pure tetrahydroisoquinoline scaffolds, a privileged structure in medicinal chemistry.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.
• Chemical Biology Probes: Used in the development of molecular probes to study biological pathways and protein function.

Basic Information

Product Name	(R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1638668-18-4
Molecular Formula	C₁₆H₂₆BrNOSi
Molecular Weight	356.38 g/mol
Synonyms	(R)-5-Bromo-3-(((tert-butyldimethylsilyl)oxy)methyl)-1,2,3,4-tetrahydroisoquinoline; (R)-5-Bromo-3-((tert-butyldimethylsilyloxy)methyl)-1,2,3,4-tetrahydroisoquinoline; (R)-5-Bromo-3-(((TBDMS)Oxy)Methyl)-1,2,3,4-Tetrahydroisoquinoline; (R)-5-Bromo-3-(TBDMS-oxymethyl)-1,2,3,4-tetrahydroisoquinoline; (R)-5-Bromo-3-((tert-butyldimethylsiloxy)methyl)-3,4-dihydro-1H-isoquinoline; 1,2,3,4-Tetrahydroisoquinoline, 5-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-, (3R)-
EINECS	Contact for details

Quality Control

Our (R)-5-Bromo-3-(((tert-Butyldimethylsilyl)Oxy)Methyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.