Description

(R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylicacid is a high-purity chiral building block of significant importance in modern synthetic chemistry. This compound serves as a critical intermediate for the development of novel pharmaceuticals and bioactive molecules, particularly those targeting neurological and cardiovascular pathways. It is primarily utilized by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in the synthesis of complex, stereospecific active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and cardiovascular therapeutic areas.
• Peptidomimetic Chemistry: Used in the construction of constrained peptide analogs and peptidomimetics due to its tetrahydroisoquinoline scaffold.
• Asymmetric Synthesis: Employed as a starting material or resolving agent in asymmetric catalytic processes to introduce chirality into target molecules.
• Medicinal Chemistry Research: A valuable tool compound for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Used to develop molecular probes for studying enzyme function and biological pathways.
• Fine Chemical Production: Serves as a precursor for the manufacture of more complex, high-value specialty chemicals.

Basic Information

Product Name	(R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylicacid
CAS No.	1638668-15-1
Molecular Formula	C10H10BrNO2
Molecular Weight	256.10 g/mol
Synonyms	(3R)-5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (R)-5-Bromo-Tic-OH; 5-Bromo-D-Tic-OH; (R)-5-Bromo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 5-Bromo-(R)-Tic; (R)-5-Bromotetrahydroisoquinoline-3-carboxylic acid; BTR-1638668
EINECS	Contact for details

Quality Control

Our (R)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylicacid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and chiral integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.