Description

3-Bromo-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrazole-5-Carbonitrile is a high-value, functionalized pyrazole derivative designed for advanced synthetic chemistry. This compound serves as a critical versatile building block in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is essential for R&D chemists and process development scientists working on novel active ingredients, offering a unique combination of a bromo-substituent and a protected hydroxymethyl group for selective functionalization.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing pyrazole or heterocyclic cores for targeted therapies.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the pyrazole scaffold is a common bioactive motif.
• Material Science Chemistry: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Chemical Biology & Proteomics: Utilized as a tagged scaffold or linker in the development of chemical probes and bioconjugation tools.
• Academic & Contract Research: A valuable reagent for methodology development and exploring new synthetic pathways in academic and industrial R&D laboratories.

Basic Information

Item	Detail
Product Name	3-Bromo-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrazole-5-Carbonitrile
CAS No.	1637595-30-2
Molecular Formula	C11H18BrN3OSi
Molecular Weight	332.27 g/mol
Synonyms	3-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-5-carbonitrile; 3-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-5-carbonitrile; 1-[(2-Trimethylsilylethoxy)methyl]-3-bromo-1H-pyrazole-5-carbonitrile; 3-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-5-carbonitrile; 1H-Pyrazole-5-carbonitrile, 3-bromo-1-[(2-(trimethylsilyl)ethoxy)methyl]-; 3-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-5-carbonitrile (SEM-protected bromopyrazole carbonitrile)
EINECS	Contact for details

Quality Control

Our 3-Bromo-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1H-Pyrazole-5-Carbonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.