Description

Ethyl 5-Methanesulfonamido-1-benzothiophene-2-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its benzothiophene core structure. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new therapeutic agents, especially those targeting complex disease pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly those with benzothiophene scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Development: Serves as a building block for compounds targeting various kinase enzymes, which are implicated in cancer and inflammatory diseases.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of bespoke organic molecules for client-specific research programs.

Basic Information

Product Name	Ethyl 5-Methanesulfonamido-1-benzothiophene-2-carboxylate
CAS No.	1631712-98-5
Molecular Formula	C₁₃H₁₅NO₄S₂
Molecular Weight	313.39 g/mol
Synonyms	Ethyl 5-(methylsulfonamido)benzo[b]thiophene-2-carboxylate; 5-Methanesulfonamido-1-benzothiophene-2-carboxylic Acid Ethyl Ester; 1-Benzothiophene-2-carboxylic acid, 5-[(methylsulfonyl)amino]-, ethyl ester; Ethyl 5-[(methylsulfonyl)amino]-1-benzothiophene-2-carboxylate; CAS 1631712-98-5
EINECS	Contact for details

Quality Control

Our Ethyl 5-Methanesulfonamido-1-benzothiophene-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.