Description

5,7-Dichloro-2-Trideuteromethyl-2H-Pyrazolo[4,3-D]Pyrimidine is a high-value, deuterated heterocyclic compound used as a key intermediate in advanced pharmaceutical research and development. Its core value lies in the strategic incorporation of deuterium atoms, which can significantly alter the metabolic profile and pharmacokinetics of lead drug candidates. This compound is essential for medicinal chemists and R&D teams in the pharmaceutical and biotechnology sectors focused on developing novel therapeutics with improved efficacy and safety.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of deuterated drug candidates, particularly in kinase inhibitor programs.
• Metabolic Stability Studies: Used in the development of compounds with enhanced metabolic stability and prolonged half-life through the deuterium kinetic isotope effect (DKIE).
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a versatile linker or warhead component in the design of targeted protein degraders.
• Biochemical Research: Employed as a tool compound for probing enzyme mechanisms and biological pathways.
• Isotope Labeling: Acts as a precursor for the synthesis of more complex molecules labeled with stable isotopes for use in mass spectrometry and NMR studies.
• Preclinical Development: Supports the synthesis of compounds for ADME (Absorption, Distribution, Metabolism, and Excretion) and toxicology evaluations.

Basic Information

Product Name	5,7-Dichloro-2-Trideuteromethyl-2H-Pyrazolo[4,3-D]Pyrimidine
CAS No.	1630907-06-0
Molecular Formula	C7H2D3Cl2N5
Molecular Weight	235.09 g/mol
Synonyms	2-(Trideuteromethyl)-5,7-dichloro-2H-pyrazolo[4,3-d]pyrimidine; 5,7-Dichloro-2-(trideuteromethyl)-2H-pyrazolo[4,3-d]pyrimidine; 2H-Pyrazolo[4,3-d]pyrimidine, 5,7-dichloro-2-(trideuteromethyl)-; Deuterated Sildenafil Intermediate; 5,7-Dichloro-2-(CD3)-2H-pyrazolo[4,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 5,7-Dichloro-2-Trideuteromethyl-2H-Pyrazolo[4,3-D]Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive pharmaceutical R&D. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), isotopic enrichment, and impurity profiles. We adhere to cGMP principles for advanced intermediates, ensuring traceability and documentation suitable for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.