Description

3-Boc-8-Cbz-3,8-Diazabicyclo[4.2.0]Octane is a high-value, protected bicyclic diamine building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research and the development of novel pharmaceutical agents, particularly as a key intermediate for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A crucial scaffold for synthesizing drug candidates targeting central nervous system (CNS) disorders, GPCRs, and enzyme inhibitors.
• Medicinal Chemistry Research: Used in parallel and combinatorial libraries for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Synthesis: Serves as a constrained diamine surrogate to introduce rigidity into peptide backbones, enhancing metabolic stability and bioavailability.
• Ligand and Catalyst Development: Employed in the preparation of novel chiral ligands for asymmetric catalysis and organometallic complexes.
• Chemical Biology Probes: Useful for constructing molecular probes to study biological pathways and protein function.
• Agrochemical Active Ingredient Synthesis: Acts as a building block for novel herbicides, fungicides, and insecticides requiring specific stereochemistry.

Basic Information

Product Name	3-Boc-8-Cbz-3,8-Diazabicyclo[4.2.0]Octane
CAS No.	1630906-87-4
Molecular Formula	C20H28N2O4
Molecular Weight	360.45 g/mol
Synonyms	tert-Butyl 8-[(benzyloxy)carbonyl]-3,8-diazabicyclo[4.2.0]octane-3-carboxylate; 3-(tert-Butoxycarbonyl)-8-(benzyloxycarbonyl)-3,8-diazabicyclo[4.2.0]octane; 3-N-Boc-8-N-Cbz-3,8-Diazabicyclo[4.2.0]octane; BOC-CBZ-DABCO Derivative; Protected 3,8-Diazabicyclo[4.2.0]octane; Bicyclic Diamine Building Block
EINECS	Contact for details

Quality Control

Our 3-Boc-8-Cbz-3,8-Diazabicyclo[4.2.0]Octane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with REACH and other global regulatory frameworks, and can provide material suitable for use under cGMP guidelines for non-clinical development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and purity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.