Description

Palbociclib-D8 CAS NO 1628752-83-9 is a deuterated analog of the cyclin-dependent kinase (CDK) 4/6 inhibitor Palbociclib, where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, such as LC-MS/MS, ensuring high accuracy and reproducibility in pharmacokinetic and metabolism studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on oncology drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS analysis in bioanalytical method development and validation.
• Quantification of Palbociclib and its metabolites in biological matrices (plasma, serum, tissue) for pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Drug metabolism and disposition (DMPK) research to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Palbociclib.
• Clinical trial support, ensuring reliable and GLP-compliant data for regulatory submissions to agencies like the FDA and EMA.
• Use in stable isotope dilution assays to achieve superior precision and accuracy over non-labeled standards.
• Research tool in academic and industrial settings studying CDK4/6 inhibition mechanisms and resistance.

Basic Information

Product Name	Palbociclib-D8
CAS No.	1628752-83-9
Molecular Formula	C24H21D8N7O2
Molecular Weight	447.58 g/mol
Synonyms	6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one-D8; IBRANCE-D8; PD-0332991-D8; (S)-6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8H-pyrido[2,3-d]pyrimidin-7-one-D8; Deuterated Palbociclib; Palbociclib (hexadeutero); CDK4/6 Inhibitor-D8
EINECS	Contact for details

Quality Control

Our Palbociclib-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic enrichment, and residual solvents. We adhere to relevant industry standards to support your GLP and GMP compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.