Description

2-Amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique thiophene core substituted with a trifluoroethyl group and a primary amide. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation drug candidates with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug molecules, especially in neurology and psychiatry.
• Agrochemical Research: Used in the discovery of novel pesticides and herbicides, leveraging the bioactivity of the thiophene scaffold.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialized polymers and organic electronic materials.
• Chemical Biology Probe: Employed in academic and industrial research to study enzyme interactions and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	2-Amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxamide
CAS No.	1628317-82-7
Molecular Formula	C7H7F3N2OS
Molecular Weight	224.20 g/mol
Synonyms	2-Amino-5-(2,2,2-trifluoroethyl)-3-thiophenecarboxamide; 5-(2,2,2-Trifluoroethyl)-2-aminothiophene-3-carboxamide; 2-Amino-5-(trifluoroethyl)thiophene-3-carboxylic acid amide; Thiophene-3-carboxamide, 2-amino-5-(2,2,2-trifluoroethyl)-; 1628317-82-7; ATFTC; 2-Amino-5-(trifluoroethyl)-3-carbamoylthiophene
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.