Description

tert-Butyl 6-Fluoro-3-Iodo-1H-Indole-1-Carboxylate is a high-purity, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and iodine atoms on the indole scaffold, enabling precise downstream functionalization for creating complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in developing new generation herbicides and fungicides, leveraging the bioactivity of the halogenated indole core.
• Material Science: Serves as a monomer or functional unit in the creation of organic electronic materials and advanced polymers.
• Cross-Coupling Reactions: The 3-iodo group is an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form carbon-carbon bonds.
• Fluorine Chemistry: The 6-fluoro substituent is utilized to study metabolic stability, bioavailability, and binding affinity in medicinal chemistry programs.
• Academic & Contract Research: A valuable reagent for methodological development and exploring new synthetic pathways in academic and industrial R&D laboratories.

Basic Information

Product Name	tert-Butyl 6-Fluoro-3-Iodo-1H-Indole-1-Carboxylate
CAS No.	1627722-96-6
Molecular Formula	C13H13FINO2
Molecular Weight	361.15 g/mol
Synonyms	1-Boc-6-fluoro-3-iodoindole; 6-Fluoro-3-iodo-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 6-fluoro-3-iodoindole-1-carboxylate; 1-(tert-Butoxycarbonyl)-6-fluoro-3-iodo-1H-indole; Boc-6-F-3-I-indole; 1627722-96-6; 6-Fluoro-3-iodoindole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 6-Fluoro-3-Iodo-1H-Indole-1-Carboxylate is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.