Description

Ethyl 2-Amino-6-(3,5-Dimethylisoxazol-4-Yl)-5-Methoxy-1H-Indole-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound matters for its role as a key building block in the synthesis of novel, complex heterocyclic molecules, enabling the development of new therapeutic agents. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing innovative small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

This specialized indole derivative serves as a critical precursor in several advanced chemical synthesis pathways.

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the biological activity of lead compounds.
• Heterocyclic Compound Synthesis: Serves as a core scaffold for constructing complex molecular libraries containing fused indole and isoxazole rings.
• Contract Research & Development (CRO): Supplied to CROs and CDMOs for custom synthesis projects and process development.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and novel methodology development.
• Bioconjugate Development: Potential use in creating targeted drug conjugates due to its functionalizable amine and ester groups.

Basic Information

Product Name	Ethyl 2-Amino-6-(3,5-Dimethylisoxazol-4-Yl)-5-Methoxy-1H-Indole-3-Carboxylate
CAS No.	1627721-54-3
Molecular Formula	C₁₇H₁₉N₃O₄
Molecular Weight	329.35 g/mol
Synonyms	Ethyl 2-amino-6-(3,5-dimethyl-4-isoxazolyl)-5-methoxy-1H-indole-3-carboxylate; 1H-Indole-3-carboxylic acid, 2-amino-6-(3,5-dimethyl-4-isoxazolyl)-5-methoxy-, ethyl ester; 1627721-54-3; 2-Amino-6-(3,5-dimethylisoxazol-4-yl)-5-methoxy-1H-indole-3-carboxylic acid ethyl ester; 6-(3,5-Dimethylisoxazol-4-yl)-5-methoxy-2-aminoindole-3-carboxylate ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-6-(3,5-Dimethylisoxazol-4-Yl)-5-Methoxy-1H-Indole-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment, and we support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.