Description

Vitamin D3-D7 (CAS 1627523-19-6) is a high-purity, deuterated analog of cholecalciferol (Vitamin D3), where seven hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is critical for advanced research and analytical applications, providing an essential internal standard for precise quantification. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of diagnostic kits requiring exceptional accuracy in mass spectrometry and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial reference compound for the accurate quantification of endogenous Vitamin D3 and its metabolites in complex biological matrices like serum, plasma, and tissues.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetic (DMPK) studies to trace and understand the metabolic pathways of Vitamin D3 and related drug candidates.
• Clinical Diagnostics: Enables the development and calibration of high-sensitivity assays for measuring Vitamin D status, crucial for diagnosing deficiencies and monitoring therapy.
• Nutritional Science Studies: Facilitates precise research into Vitamin D3 absorption, bioavailability, and turnover in nutritional and metabolic research.
• Stable Isotope Labeling: Acts as a tracer in mechanistic biochemical studies to investigate the role and fate of Vitamin D3 in physiological processes.
• Quality Control Reference: Provides a certified reference material for ensuring the accuracy and reliability of analytical methods in quality control laboratories.

Basic Information

Product Name	Vitamin D3-D7
CAS No.	1627523-19-6
Molecular Formula	C₂₇H₃₈D₇O
Molecular Weight	~391.7 g/mol
Synonyms	Cholecalciferol-d7; (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol-d7; Vitamin D3-d7; 7-Deuterio Vitamin D3; [²H₇]-Cholecalciferol; Stable Isotope Labeled Vitamin D3; Ergocalciferol-d7 (common misnomer, correct is cholecalciferol-d7)
EINECS	Contact for details

Quality Control

Every batch of our Vitamin D3-D7 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, HPLC, and mass spectrometry to ensure identity, potency, and isotopic enrichment. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and solvent residues are provided. Our production adheres to cGMP guidelines for active pharmaceutical ingredients (APIs) and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at controlled room temperature (15-25°C) or as specified on the label. This product is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.