Description

tert-Butyl 6-(Chlorosulfonyl)-8-Fluoro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-value, multi-functional chemical intermediate designed for advanced synthetic chemistry. This compound is critical for pharmaceutical research and development, particularly in constructing complex molecular scaffolds. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorinated isoquinoline core for enhanced bioactivity.
• Chemical Biology Probe Synthesis: The reactive chlorosulfonyl group enables conjugation, making it valuable for creating labeled compounds and molecular probes for target identification and validation.
• Peptidomimetic & Scaffold Development: Serves as a constrained scaffold in the design of peptidomimetics and other biologically active molecules with improved metabolic stability.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or organic electronic materials requiring fluorinated aromatic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 6-(Chlorosulfonyl)-8-Fluoro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	1627099-46-0
Molecular Formula	C14H15ClFNO4S
Molecular Weight	347.79 g/mol
Synonyms	1,2,3,4-Tetrahydro-8-fluoro-6-(chlorosulfonyl)isoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 8-fluoro-1,2,3,4-tetrahydro-6-isoquinolinesulfonyl chloride-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 6-(chlorosulfonyl)-8-fluoro-3,4-dihydro-, 1,1-dimethylethyl ester; 8-Fluoro-6-(chlorosulfonyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; Boc-8-fluoro-6-chlorosulfonyl-THIQ; tert-Butyl 8-fluoro-6-sulfonylchloride-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 1627099-46-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Chlorosulfonyl)-8-Fluoro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting development work under ISO, GMP, or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.