Description

(4As,8Ar)-tert-Butyl 6,7-Dihydroxyoctahydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex organic molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) for use in the development of new therapeutic agents, including potential candidates for neurological and cardiovascular applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Asymmetric Synthesis: Serves as a precursor for the construction of complex natural product analogs and other stereochemically defined molecules.
• Neurological Drug Development: Potential scaffold for the development of compounds targeting central nervous system (CNS) disorders.
• Chemical Biology Probes: Can be utilized in the development of molecular probes to study biological pathways and enzyme functions.
• Process Chemistry: Used in the development and scale-up of efficient synthetic routes for target molecules under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	(4As,8Ar)-tert-Butyl 6,7-Dihydroxyoctahydroisoquinoline-2(1H)-Carboxylate
CAS No.	1624258-64-5
Molecular Formula	C₁₄H₂₅NO₄
Molecular Weight	271.35 g/mol
Synonyms	tert-Butyl (4aS,8aR)-6,7-dihydroxy-1,2,3,4,4a,5,8,8a-octahydroisoquinoline-2-carboxylate; (4aS,8aR)-2-(tert-Butoxycarbonyl)-1,2,3,4,4a,5,8,8a-octahydroisoquinoline-6,7-diol; 6,7-Dihydroxyoctahydroisoquinoline-2-carboxylic acid tert-butyl ester (stereospecific); BOC-Protected Octahydroisoquinoline Diol Derivative; (4aS,8aR)-Boc-6,7-dihydroxyoctahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (4As,8Ar)-tert-Butyl 6,7-Dihydroxyoctahydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.