Description

T-Butyoxycarboxy-Peg4-Phosphonic Acid Ethyl Ester is a high-purity, functionalized PEG-phosphonate derivative designed for advanced chemical synthesis. This compound is a critical building block for introducing hydrophilic, spacer-linked phosphonic acid groups into target molecules under mild conditions. It is primarily utilized by researchers and process chemists in the pharmaceutical, bioconjugation, and materials science industries for creating novel drug conjugates, surface modifiers, and functional polymers.

Application

• Pharmaceutical Linker Chemistry: Serves as a key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates, providing a hydrophilic PEG spacer and a protected phosphonic acid handle.
• Surface Functionalization: Used to modify nanoparticles, quantum dots, and medical device surfaces to impart hydrophilicity and enable further covalent attachment of biomolecules.
• Prodrug Synthesis: Employed in the design of prodrugs where a phosphonate moiety is required for targeted drug release or enhanced bioavailability.
• Polymer Modification: Acts as a functional monomer or end-group modifier for creating specialty polymers with tailored solubility and reactivity profiles.
• Chemical Biology Probes: Utilized in the development of activity-based probes and diagnostic agents that require a stable, water-soluble linker.
• Catalyst and Ligand Design: Provides a scaffold for constructing novel ligands and catalysts in organometallic chemistry and asymmetric synthesis.

Basic Information

Product Name	T-Butyoxycarboxy-Peg4-Phosphonic Acid Ethyl Ester
CAS No.	1623791-77-4
Molecular Formula	C20H40NO11P
Molecular Weight	501.50 g/mol
Synonyms	Boc-PEG4-phosphonic acid ethyl ester; (Ethoxycarbonyloxy-tert-butyl)-PEG4-phosphonic acid ethyl ester; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-[(1,1-dimethylethoxy)carbonyl]-13-oxo-, ethyl ester, P-oxide; t-Boc-NH-PEG4-phosphonate ethyl ester; tert-Butyl (13-ethoxy-13-oxo-3,6,9,12-tetraoxa-13-phosphapentadecan-15-yl)carbamate 13-oxide; PEG4-Boc-phosphonate ethyl ester; Boc-protected tetraethylene glycol phosphonate ethyl ester.
EINECS	Contact for details

Quality Control

Our T-Butyoxycarboxy-Peg4-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.