Description

(4S)-4-(sec-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole is a high-purity chiral oxazoline derivative, a crucial class of compounds valued for their role as ligands and intermediates in asymmetric synthesis. Its specific stereochemistry and functional groups make it an essential building block for creating enantiomerically pure pharmaceuticals and fine chemicals. This product is primarily targeted at research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality chiral auxiliaries.

Application

• Asymmetric Catalysis: Serves as a key chiral ligand or precursor for ligands in transition metal-catalyzed reactions, such as asymmetric hydrogenation, cyclopropanation, and Diels-Alder reactions.
• Pharmaceutical Intermediate: Used in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for complex molecules requiring specific stereocenters.
• Agrochemical Synthesis: Employed in the development of chiral pesticides and herbicides where biological activity is stereospecific.
• Material Science Research: Acts as a monomer or functional additive in the development of chiral polymers and advanced organic materials with specific optical properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research within university and corporate laboratories.

Basic Information

Product Name	(4S)-4-(sec-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole
CAS No.	1620588-66-0
Molecular Formula	C12H16N2O
Molecular Weight	204.27 g/mol
Synonyms	(4S)-4-(1-Methylpropyl)-2-(2-pyridinyl)-4,5-dihydrooxazole; (S)-4-(sec-Butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole; 2-(2-Pyridyl)-4-(sec-butyl)-δ⁴-oxazoline (S-form); (S)-2-(2-Pyridinyl)-4-(1-methylpropyl)-2-oxazoline; Chiral Pyridyl Oxazoline Ligand Precursor; (S)-PB Oxazoline
EINECS	Contact for details

Quality Control

Our (4S)-4-(sec-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for sensitive asymmetric synthesis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.