Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester group and a trifluoromethyl-substituted pyrrolopyridine core. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas, including oncology and central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) in drug discovery programs through efficient biaryl bond formation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Precursor: Serves as a monomer or functional unit in the creation of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds and molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1620574-99-3
Molecular Formula	C16H20BF3N2O2
Molecular Weight	340.15 g/mol
Synonyms	3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 3-(Trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine adheres to stringent GMP and ISO 9001 guidelines, ensuring batch-to-batch consistency and high purity for critical research and manufacturing. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with your specified requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.