Description

(3R,5R,8R,9S,10S,13S,14S)-2,2,3,4,4-Pentadeuterio-3-Hydroxy-10,13-Dimethyl-5,6,7,8,9,11,12,14,15,16-Decahydro-1H-Cyclopenta[A]Phenanthren-17-One is a high-purity, deuterium-labeled steroid derivative, specifically designed for advanced analytical and research applications. This compound is critical for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic studies with enhanced sensitivity and accuracy. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors who require reliable, isotopically labeled reference materials for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of steroid hormones and related metabolites in complex biological matrices such as serum, plasma, and urine.
• Metabolic Pathway Tracing: Enables detailed studies of steroid biosynthesis, metabolism, and degradation pathways in pharmacological and biochemical research.
• Pharmaceutical R&D: Serves as a critical reference material in the development and validation of bioanalytical methods for new drug candidates targeting hormonal pathways.
• Clinical Diagnostics: Supports the development of high-precision diagnostic assays for endocrine disorders, including adrenal and gonadal function tests.
• Doping Control Analysis: Employed in sports anti-doping laboratories as a deuterated standard for the confirmatory analysis of endogenous anabolic steroids.
• Stable Isotope Labeling Studies: Facilitates research in pharmacokinetics, bioavailability, and drug metabolism studies (DMPK) due to its isotopic purity.

Basic Information

Product Name	(3R,5R,8R,9S,10S,13S,14S)-2,2,3,4,4-Pentadeuterio-3-Hydroxy-10,13-Dimethyl-5,6,7,8,9,11,12,14,15,16-Decahydro-1H-Cyclopenta[A]Phenanthren-17-One
CAS No.	1620102-33-1
Molecular Formula	C19H25D5O2
Molecular Weight	299.47 g/mol (approx.)
Synonyms	3-Hydroxy-10,13-dimethyl-2,2,3,4,4-pentadeuterio-1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-17H-cyclopenta[a]phenanthren-17-one; Deuterated Androstanedione Derivative; [2,2,3,4,4-2H5]-3-Hydroxyandrostane-17-one; Pentadeuterated 3-Hydroxyandrostanedione; Isotopically Labeled Steroid Standard; 3α-Hydroxy-5α-androstane-17-one-d5; 5α-Androstane-3α-ol-17-one-d5
EINECS	Contact for details

Quality Control

Every batch of this deuterated compound is produced and analyzed under strict quality protocols to ensure high isotopic and chemical purity, which is paramount for its use as an analytical standard. Our quality assurance includes comprehensive testing via NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing the isotopic enrichment, chemical purity, and results of all identity and purity tests. We support compliance with GMP/GLP principles for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.