Description

5-Chlorosaligenyl- N , N -Diisopropylphosphoramidite is a key phosphoramidite monomer used in the automated synthesis of oligonucleotides. This compound matters as a critical building block for introducing specific modifications into DNA or RNA sequences, enabling advanced research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories working on antisense oligonucleotides, siRNA, aptamers, and other nucleic acid-based technologies. Its reliable quality is essential for ensuring high coupling efficiency and final oligo purity.

Application

• Solid-Phase Oligonucleotide Synthesis: As a phosphoramidite reagent for the automated chemical synthesis of modified DNA and RNA strands.
• Antisense Oligonucleotide (ASO) Development: For creating therapeutic oligonucleotides targeting specific mRNA sequences.
• siRNA and miRNA Synthesis: Used in the production of short interfering RNA (siRNA) and microRNA (miRNA) for gene silencing applications.
• Aptamer Production: Enables the incorporation of modified nucleotides to enhance aptamer stability and binding affinity.
• Diagnostic Probe Manufacture: For labeling or modifying oligonucleotide probes used in diagnostics and bioassays.
• Research Scale Nucleic Acid Chemistry: A vital reagent in academic and industrial labs exploring novel nucleic acid structures and functions.

Basic Information

Product Name	5-Chlorosaligenyl- N , N -Diisopropylphosphoramidite
CAS No.	1620086-77-2
Molecular Formula	C19H24ClNO3P
Molecular Weight	380.82 g/mol
Synonyms	5-Chloro-2-hydroxybenzyl N,N-Diisopropylphosphoramidite; 5-Chlorosalicyl Alcohol N,N-Diisopropylphosphoramidite; 2-(((Bis(propan-2-yl)amino)(chloro)phosphanyl)oxy)methyl)-4-chlorophenol; 5-Chloro-2-(((diisopropylamino)chlorophosphino)oxy)methyl)phenol; Chlorosaligenyl Phosphoramidite; 5-Cl-Saligenyl Phosphoramidite
EINECS	Contact for details

Quality Control

Our 5-Chlorosaligenyl- N , N -Diisopropylphosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
31P NMR	Single major peak

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.