Description

Monomethyl Fumarate-D3 CAS NO 1616345-41-5 is a deuterated isotopologue of monomethyl fumarate, a key intermediate in pharmaceutical research and development. This compound is specifically valued for its use as an internal standard in quantitative mass spectrometry, enabling precise pharmacokinetic and metabolic studies. It is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing and analyzing deuterated drug substances and metabolites.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the accurate quantification of monomethyl fumarate and related compounds in biological matrices.
• Pharmaceutical R&D: Used in the development and validation of analytical methods for deuterated drug candidates and their metabolites.
• Metabolic Studies: Facilitates tracing and understanding the metabolic pathways and bioavailability of fumarate-based therapeutics.
• Stable Isotope Labeling: Acts as a labeled building block for synthesizing more complex deuterated molecules for research purposes.
• Quality Control: Employed in in-house quality control laboratories to ensure the accuracy and precision of assay methods for active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	Monomethyl Fumarate-D3
CAS No.	1616345-41-5
Molecular Formula	C5H3D3O4
Molecular Weight	131.11 g/mol (approx.)
Synonyms	Monomethyl Fumarate-d3; (2E)-But-2-enedioic acid-2,3,3-d3 methyl ester; Methyl Hydrogen Fumarate-d3; Methyl (2E)-2-butenedioate-2,3,3-d3; Fumaric Acid Monomethyl Ester-d3; MMF-d3; Dimethyl Fumarate Impurity F-d3 (monomethyl ester)
EINECS	Contact for details

Quality Control

Our Monomethyl Fumarate-D3 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ²H) and HPLC to confirm chemical structure, isotopic purity (D-enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to ensure it meets the stringent requirements for analytical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.