Description

(R)-2-(Oxiran-2-Ylmethyl)-1,2,3,4-Tetrahydroisoquinoline is a chiral epoxide-containing tetrahydroisoquinoline derivative, a high-value building block in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecules with precise stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in asymmetric synthesis and medicinal chemistry programs. The product is supplied under stringent quality control to ensure batch-to-batch consistency for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a pivotal chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce the tetrahydroisoquinoline scaffold with defined stereochemistry.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery campaigns.
• Agrochemical Development: Acts as a building block for creating chiral active ingredients with enhanced efficacy and selectivity.
• Ligand and Catalyst Preparation: Utilized in the synthesis of chiral ligands or organocatalysts for enantioselective transformations.
• Fine Chemical Production: Incorporated into the synthesis of specialty chemicals requiring the tetrahydroisoquinoline moiety.

Basic Information

Product Name	(R)-2-(Oxiran-2-Ylmethyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1616064-77-7
Molecular Formula	C₁₂H₁₅NO
Molecular Weight	189.25 g/mol
Synonyms	(R)-2-(Oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline; (R)-2-((Oxiran-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline; (R)-1,2,3,4-Tetrahydro-2-[(2-oxiranyl)methyl]isoquinoline; (R)-2-Glycidyl-1,2,3,4-tetrahydroisoquinoline; (2R)-2-[(Oxiran-2-yl)methyl]-1,2,3,4-tetrahydroisoquinoline; (R)-Tetrahydroisoquinoline glycidyl ether; Chiral tetrahydroisoquinoline epoxide
EINECS	Contact for details

Quality Control

Our (R)-2-(Oxiran-2-Ylmethyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and development use. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment. We support cGMP-compliant production for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.