Description

Endo-6-(Boc-Amino)-3-Azabicyclo[3.1.1]Heptane CAS NO 1614256-81-3 is a high-purity, advanced pharmaceutical intermediate featuring a protected amino group on a rigid bicyclic scaffold. This compound is a critical building block for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and target selectivity. It is primarily utilized by pharmaceutical companies and research institutions in the development of central nervous system (CNS) therapeutics, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of various enzymatic targets.
• CNS Drug Discovery: Employed in the development of therapeutics targeting neurological disorders due to its ability to influence blood-brain barrier penetration.
• Peptidomimetics: Acts as a constrained, non-peptide backbone mimic to enhance the stability and bioavailability of peptide-based drugs.
• Asymmetric Synthesis: Provides a chiral template for the construction of complex, enantiomerically pure molecules.

Basic Information

Product Name	Endo-6-(Boc-Amino)-3-Azabicyclo[3.1.1]Heptane
CAS No.	1614256-81-3
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	endo-6-[(tert-Butoxycarbonyl)amino]-3-azabicyclo[3.1.1]heptane; 6-endo-(Boc-Amino)-3-azabicyclo[3.1.1]heptane; (1S,5R)-6-[(tert-Butoxycarbonyl)amino]-3-azabicyclo[3.1.1]heptane; tert-Butyl N-[(1S,5R)-3-azabicyclo[3.1.1]heptan-6-yl]carbamate; Boc-3-Azabicyclo[3.1.1]heptan-6-amine, endo-; 3-Azabicyclo[3.1.1]heptane-6-carboxamide, N-(tert-butoxy)-, (1S,5R)-; Boc-AABH-endo-6-amine
EINECS	Contact for details

Quality Control

Our Endo-6-(Boc-Amino)-3-Azabicyclo[3.1.1]Heptane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical and chiral purity suitable for advanced research and pre-clinical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.