Description

Escin Ie is a high-purity, standardized saponin compound derived from horse chestnut (*Aesculus hippocastanum*). This specific isomer is valued for its consistent bioactivity and serves as a critical reference standard and active ingredient in advanced research and development. It is essential for pharmaceutical, nutraceutical, and cosmetic manufacturers requiring precise, reliable, and well-characterized botanical actives. The compound is supplied under strict quality control to ensure batch-to-batch consistency for demanding industrial applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and purity testing of escin-based drug products in quality control laboratories.
• Venotonic Drug Formulation: A key active pharmaceutical ingredient (API) in the development and production of medications for chronic venous insufficiency (CVI), hemorrhoids, and post-operative edema.
• Nutraceutical & Dietary Supplements: Incorporated into capsules, tablets, and tinctures aimed at supporting vascular health and reducing inflammation.
• Cosmetic & Skincare Actives: Formulated into creams, serums, and gels for its anti-inflammatory and capillary-strengthening properties, targeting under-eye circles, puffiness, and cellulite appearance.
• Biomedical Research: Employed in *in vitro* and *in vivo* studies to investigate mechanisms of action related to inflammation, vascular permeability, and oxidative stress.
• Analytical Chemistry: Serves as a critical standard for method development and validation in HPLC, LC-MS, and other analytical techniques for botanical extract analysis.

Basic Information

Item	Details
Product Name	Escin Ie
CAS No.	1613506-26-5
Molecular Formula	C55H86O24
Molecular Weight	1131.3 g/mol
Synonyms	Aescin Ie; Escin Ia; β-Escin; Escin (main component); Aesculus saponin; Horse Chestnut Saponin Ie; 21-Benzoyltrogoxigenin 3-[2-O-(2-methylbutyryl)-β-D-glucopyranoside]; 3-O-[2-O-(2-Methylbutyryl)-β-D-glucopyranosyl]-21-O-benzoyl-28-O-β-D-glucopyranosylprotoaescigenin
EINECS	Contact for details

Quality Control

Every batch of Escin Ie is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) with results from HPLC, NMR, and MS to verify identity, purity, and conformity to specifications. Our quality commitment ensures the material is suitable for use as a pharmaceutical reference standard and meets the stringent requirements of GMP-compliant production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.