Description

(±)-1-Isopropyl-D7-Amino-3-(1-Naphthyloxy)-2-Propanol Hydrochloride CAS NO 1613439-56-7 is a high-purity, deuterium-labeled derivative of propranolol, a well-known β-blocker. This compound is specifically engineered for use as a critical internal standard in quantitative bioanalytical research, ensuring unparalleled accuracy in mass spectrometry and pharmacokinetic studies. It is an essential reagent for pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic developers focused on cardiovascular drug metabolism, clinical toxicology, and advanced analytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of propranolol and related compounds in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmaceutical R&D & Metabolism Studies: Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) profiling, absorption, distribution, metabolism, and excretion (ADME) studies for β-blocker development.
• Clinical and Forensic Toxicology: Used in assays to monitor drug levels, confirm compliance, and investigate cases of overdose or adverse drug reactions involving β-blockers.
• Method Development & Validation: Serves as a key component in developing, optimizing, and validating robust, GLP-compliant analytical methods in regulated laboratories.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques where the deuterium label compensates for sample preparation and ionization variability.
• Reference Material for Certified Standards: Acts as a high-purity starting material for manufacturers of certified reference materials (CRMs) and quality control standards.

Basic Information

Item	Details
Product Name	(±)-1-Isopropyl-D7-Amino-3-(1-Naphthyloxy)-2-Propanol Hydrochloride
CAS No.	1613439-56-7
Molecular Formula	C₁₆H₁₅D₇ClNO₂
Molecular Weight	310.86 g/mol (approx.)
Synonyms	Propranolol-d7 Hydrochloride; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol-d7 Hydrochloride; (±)-Propranolol-d7 HCl; DL-Propranolol-d7 Hydrochloride; 1-(Isopropyl-d7-amino)-3-(naphthalen-1-yloxy)propan-2-ol Hydrochloride; ICI 45520-d7; NSC 91523-d7
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is manufactured and controlled to meet the exacting requirements of analytical research. Rigorous quality testing includes NMR and mass spectrometry for isotopic purity and structural confirmation, and HPLC for chemical purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for purity, isotopic enrichment, and identity. Our quality system supports compliance with GMP/GLP principles for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.