Description

trans-Cyclooctene-Maleimide is a high-value, strained alkene-functionalized reagent designed for advanced chemical synthesis. This compound matters for its exceptional reactivity in strain-promoted azide-alkyne cycloaddition (SPAAC) and other bioorthogonal click chemistry reactions, enabling efficient, catalyst-free conjugation under mild conditions. It is critically needed by researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors for developing targeted drug delivery systems, diagnostic probes, and functional polymers.

Application

• Bioorthogonal Click Chemistry: Enables catalyst-free, rapid, and selective conjugation with azides via SPAAC for labeling biomolecules in living systems.
• Bioconjugation & Protein Modification: Used for site-specific labeling of antibodies, enzymes, and other proteins with fluorophores, drugs, or polymers.
• Polymer & Materials Science: Serves as a key monomer or crosslinker for synthesizing functional hydrogels, smart materials, and surface coatings with tailored properties.
• Diagnostic Probe Development: Facilitates the creation of sensitive imaging agents and biosensors for in vitro and in vivo diagnostics.
• Drug Delivery System Fabrication: Employed to construct targeted nanocarriers and prodrugs through efficient ligation strategies.
• Chemical Biology Research: A vital tool for studying dynamic cellular processes through metabolic labeling and live-cell imaging.

Basic Information

Product Name	trans-Cyclooctene-Maleimide
CAS No.	1609659-01-9
Molecular Formula	C16H19NO3
Molecular Weight	273.33 g/mol
Synonyms	trans-Cyclooct-2-en-1-yl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate; TCO-Maleimide; (E)-Cyclooct-2-en-1-yl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate; Maleimide-TCO; TCO-PEG-MAL; SPAAC Reagent; trans-Cyclooctene NHS Ester analog; Bioorthogonal Maleimide Reagent
EINECS	Contact for details

Quality Control

Our trans-Cyclooctene-Maleimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioorthogonal applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For optimal performance, use immediately after preparation of solutions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.