Description

6-Fluoro-5-Nitro-1H-Indole is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique molecular structure, featuring both electron-withdrawing nitro and fluorine substituents on the indole scaffold, makes it a critical intermediate for constructing complex pharmacophores. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule drugs, particularly kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its bioactive indole core.
• Material Science: Serves as a building block for organic semiconductors, dyes, and photoactive polymers.
• Academic & R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Fluorinated Compound Synthesis: The presence of the fluorine atom makes it a valuable starting material for further fluorination chemistry and the creation of analogs with improved metabolic stability and bioavailability.

Basic Information

Product Name	6-Fluoro-5-Nitro-1H-Indole
CAS No.	1609131-18-1
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	5-Nitro-6-fluoroindole; 6-Fluoro-5-nitroindole; 1H-Indole, 6-fluoro-5-nitro-; 5-Nitro-6-fluoro-1H-indole; 6-Fluoro-5-nitro-1H-indole; 1609131-18-1
EINECS	Contact for details

Quality Control

Our 6-Fluoro-5-Nitro-1H-Indole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory requirements for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.