Description

2-Methyl-1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]-1-Propanone is a high-value, functionalized pyrazole-boronic ester derivative that serves as a critical synthetic intermediate. Its core value lies in the protected boronic acid group, which enables efficient cross-coupling reactions for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced materials science.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds in medicinal chemistry and materials research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts.
• Functional Material Research: Applied in the synthesis of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Utilized for tagging and modifying biomolecules in proteomics and diagnostic assay development.

Basic Information

Product Name	2-Methyl-1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]-1-Propanone
CAS No.	1605292-76-9
Molecular Formula	C13H21BN2O3
Molecular Weight	264.13 g/mol
Synonyms	1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)-2-methylpropan-1-one; 2-Methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-one; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylic acid isobutyryl; Isobutyryl-Protected Pyrazole Boronic Ester; 1-(4-(Pinacolatoboryl)-1H-pyrazol-1-yl)-2-methylpropan-1-one
EINECS	Contact for details

Quality Control

Our 2-Methyl-1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]-1-Propanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.