Description

1-(5-Bromo-2,3-Difluorophenyl)Ethanone is a high-purity, multi-functional aromatic ketone building block of significant importance in advanced organic synthesis. Its core value lies in the strategic placement of bromine and fluorine substituents on the phenyl ring, which allows for precise, sequential functionalization via cross-coupling and nucleophilic substitution reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require a reliable, high-quality intermediate for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorophenyl moiety enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for creating fluorinated aromatic cores essential in electronic display and lighting technologies.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and resins with tailored thermal, chemical, and optical properties.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct biaryl and complex heterocyclic systems.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and process chemistry research in both academic and industrial R&D laboratories.

Basic Information

Item	Details
Product Name	1-(5-Bromo-2,3-Difluorophenyl)Ethanone
CAS No.	1600511-63-4
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	5'-Bromo-2',3'-Difluoroacetophenone; 1-Acetyl-5-bromo-2,3-difluorobenzene; 2,3-Difluoro-5-bromoacetophenone; 5-Bromo-2,3-difluoroacetophenone; Ethanone, 1-(5-bromo-2,3-difluorophenyl)-; (5-Bromo-2,3-difluorophenyl)methyl ketone
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-2,3-Difluorophenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.