Description

4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Butanehydrazide Hydrochloride is a high-purity, functionalized chemical building block designed for advanced synthesis. This compound is valued for its unique molecular architecture, which combines a maleimide-reactive moiety with a hydrazide functional group, enabling precise bioconjugation and cross-linking applications. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and biotechnology sectors for the development of novel therapeutics, diagnostic agents, and advanced materials.

Application

• Bioconjugation Reagent: A key intermediate for site-specific conjugation of peptides, proteins, antibodies, and other biomolecules to polymers, surfaces, or drug payloads.
• Pharmaceutical Intermediate: Used in the research and development of antibody-drug conjugates (ADCs), targeted drug delivery systems, and novel small-molecule therapeutics.
• Cross-linking Agent: Facilitates the formation of stable covalent bonds in hydrogel synthesis, polymer modification, and the fabrication of biomaterials.
• Diagnostic Probe Synthesis: Serves as a linker for attaching fluorescent dyes, imaging agents, or other reporter molecules to targeting ligands.
• Chemical Biology Tool: Enables the study of protein interactions, cellular pathways, and enzyme activity through selective labeling strategies.
• Surface Functionalization: Used to modify nanoparticles, biosensor chips, and chromatography media to introduce specific reactive handles.

Basic Information

Product Name	4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Butanehydrazide Hydrochloride
CAS No.	1588441-05-7
Molecular Formula	C8H12N3O3·HCl
Molecular Weight	249.66 g/mol
Synonyms	1-(4-Hydrazinyl-4-oxobutyl)-1H-pyrrole-2,5-dione hydrochloride; 4-(2,5-Dioxopyrrolidin-1-yl)butanehydrazide hydrochloride; Maleimidobutyric hydrazide hydrochloride; 4-(Maleimid-1-yl)butyric hydrazide HCl; MBH-HCl; γ-Maleimidobutyric hydrazide hydrochloride; 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic hydrazide hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Butanehydrazide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.