Description

1-(17-Hydroxy-3,6,9,12,15-Pentaoxaheptadecyl)-1H-Pyrrole-2,5-Dione is a specialized functionalized maleimide derivative featuring a hydrophilic polyethylene glycol (PEG) spacer chain. This compound is engineered to provide a reactive handle for bioconjugation and polymer modification, offering enhanced solubility and biocompatibility. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors who require precise and stable covalent coupling strategies.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, peptides, and oligonucleotides via thiol-Michael addition or other nucleophilic reactions.
• Polymer Functionalization: As a key monomer or end-capping agent for synthesizing stimuli-responsive or bioactive PEG-based hydrogels and smart polymers.
• Drug Delivery Systems: In the development of antibody-drug conjugates (ADCs) and polymer-drug conjugates where controlled linkage is essential.
• Surface Modification: For creating biofunctional coatings on nanoparticles, diagnostic chips, and medical devices to improve biocompatibility and targeting.
• Crosslinking Agent: Used in the preparation of crosslinked networks for tissue engineering scaffolds and controlled-release matrices.
• Diagnostic Probe Synthesis: As a linker for attaching fluorophores, chelators, or other reporter molecules to targeting biomolecules.

Basic Information

Product Name	1-(17-Hydroxy-3,6,9,12,15-Pentaoxaheptadecyl)-1H-Pyrrole-2,5-Dione
CAS No.	1584544-42-2
Molecular Formula	C19H31NO9
Molecular Weight	417.45 g/mol
Synonyms	Maleimide-PEG5-OH; 1-(17-Hydroxy-3,6,9,12,15-pentaoxaheptadecyl)-1H-pyrrole-2,5-dione; 2,5-Dioxopyrrolidin-1-yl-PEG5-OH; N-(17-Hydroxy-3,6,9,12,15-pentaoxaheptadecyl)maleimide; Maleimide-PEG5-alcohol; 1-(2-(2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione; PEG5-Maleimide; Mal-PEG5-OH
EINECS	Contact for details

Quality Control

Our 1-(17-Hydroxy-3,6,9,12,15-Pentaoxaheptadecyl)-1H-Pyrrole-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and commercial applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.