Description

Tezepelumab is a high-purity, human monoclonal antibody targeting thymic stromal lymphopoietin (TSLP). This compound is a critical advanced intermediate in the research and development of innovative biologic therapeutics. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development of novel treatments for severe asthma and other inflammatory diseases. Our supply ensures the stringent quality and consistency required for preclinical and clinical-stage manufacturing.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) intermediate in the production of biologic drugs targeting TSLP-mediated pathways.
• Biomedical Research: Used as a critical reagent in in vitro and in vivo studies to investigate the role of TSLP in allergic inflammation and airway hyperresponsiveness.
• Clinical Trial Material: Supplied as a GMP-grade intermediate for the formulation of drug products used in Phase I-III clinical trials.
• Reference Standard: Employed as a high-purity analytical standard for quality control testing, method development, and validation in bioanalytical laboratories.
• Drug Discovery: Utilized in screening assays and structural biology studies to support the discovery of next-generation biologic therapies.

Basic Information

Product Name	Tezepelumab
CAS No.	1572943-04-4
Molecular Formula	C6472H10012N1736O2018S46
Molecular Weight	Approx. 145 kDa
Synonyms	AMG 157; MEDI9929; Anti-TSLP Monoclonal Antibody; TSLP mAb; Tezspire (Brand Name Intermediate); Thymic Stromal Lymphopoietin-specific Antibody; Tezepelumab-ekko (USAN)
EINECS	Contact for details

Quality Control

Our Tezepelumab is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, potency, and safety. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for critical quality attributes. We can supply material suitable for research use (RUO) or under current Good Manufacturing Practice (cGMP) guidelines for clinical applications. Relevant standards and specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is easily oxidized; solutions should be prepared under inert atmosphere when possible and used immediately.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	> 95% (Reduced & Non-reduced)
Assay (HPLC)	90.0% - 110.0% of label claim
Protein Concentration	As per COA (typically 1-10 mg/mL)
Endotoxin	< 1.0 EU/mg (for injectable grade)
Host Cell Proteins	< 100 ppm
Sterility (for aseptic grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.