Description

1,3-Bis(Cbz-Amino)-Bicyclo[1.1.1]Pentane CAS NO 1566649-44-2 is a high-value, synthetically engineered bicyclic building block featuring dual carbobenzyloxy (Cbz)-protected amine functionalities. This compound is specifically designed to serve as a critical intermediate in advanced pharmaceutical research and development, enabling the synthesis of complex molecules with enhanced metabolic stability and three-dimensional structure. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel drug candidates, particularly in the areas of protease inhibitors and targeted protein degraders (PROTACs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting challenging disease pathways.
• Protease Inhibitor Development: Used in constructing core scaffolds for inhibitors of proteolytic enzymes, relevant in virology, oncology, and inflammatory diseases.
• PROTAC & Molecular Glue Synthesis: Serves as a rigid linker or warhead component in the design of heterobifunctional degraders for targeted protein degradation therapies.
• Peptidomimetics: Incorporates non-peptide, bicyclic structures into peptide chains to improve bioavailability and resistance to enzymatic degradation.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and protein-protein interactions in biological systems.
• Agrochemical Research: Potential intermediate for creating new crop protection agents with novel modes of action.
• Material Science: Exploration into novel polymers or coatings where its rigid, three-dimensional geometry can impart unique physical properties.

Basic Information

Item	Details
Product Name	1,3-Bis(Cbz-Amino)-Bicyclo[1.1.1]Pentane
CAS No.	1566649-44-2
Molecular Formula	C21H22N2O4
Molecular Weight	366.41 g/mol
Synonyms	1,3-Bis[(benzyloxy)carbonylamino]bicyclo[1.1.1]pentane; 1,3-Bis(N-Cbz-amino)bicyclo[1.1.1]pentane; 1,3-Bis(carbobenzyloxyamino)bicyclo[1.1.1]pentane; BCP-Cbz2; Bicyclo[1.1.1]pentane-1,3-diyldicarbamic acid bis(phenylmethyl) ester; 1,3-Di-Cbz-amino-BCP; 1,3-Bis(Z-Amino)-BCP; 1,3-Bis(Cbz-NH)-BCP
EINECS	Contact for details

Quality Control

Our 1,3-Bis(Cbz-Amino)-Bicyclo[1.1.1]Pentane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under inert atmosphere. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.