Description

(1R)-1-[3-(4-Chlorophenyl)-1,2-Oxazol-5-Yl]Ethan-1-Ol CAS NO 1565845-64-8 is a high-purity chiral intermediate featuring a 1,2-oxazole (isoxazole) core substituted with a chlorophenyl group and a chiral alcohol moiety. This compound is of significant value in pharmaceutical research and development, particularly for its role as a key building block in synthesizing active pharmaceutical ingredients (APIs) with specific stereochemical requirements. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the isoxazole ring and chlorophenyl group can contribute to biological activity.
• Asymmetric Catalysis Studies: Employed as a substrate or ligand precursor in research focused on developing new asymmetric synthetic methodologies.
• Material Science Precursor: Potential use in creating functionalized organic molecules for advanced materials, such as liquid crystals or organic semiconductors.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Custom Synthesis Building Block: Available for contract research organizations (CROs) and CDMOs for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	(1R)-1-[3-(4-Chlorophenyl)-1,2-Oxazol-5-Yl]Ethan-1-Ol
CAS No.	1565845-64-8
Molecular Formula	C11H10ClNO2
Molecular Weight	223.66 g/mol
Synonyms	(1R)-1-[3-(4-Chlorophenyl)isoxazol-5-yl]ethanol; (R)-1-(3-(4-Chlorophenyl)isoxazol-5-yl)ethanol; 5-[(1R)-1-Hydroxyethyl]-3-(4-chlorophenyl)-1,2-oxazole; (R)-5-(1-Hydroxyethyl)-3-(4-chlorophenyl)isoxazole; (1R)-1-[3-(4-Chlorophenyl)-1,2-oxazol-5-yl]ethan-1-ol; (R)-3-(4-Chlorophenyl)-5-(1-hydroxyethyl)isoxazole; Chiral Isoxazole Alcohol Intermediate; CAS 1565845-64-8
EINECS	Contact for details

Quality Control

Our (1R)-1-[3-(4-Chlorophenyl)-1,2-Oxazol-5-Yl]Ethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.