Description

3-Cyclohexene-1-Carboxamide, N-[5-(3,3-Dimethyl-1-Butyn-1-Yl)-3-Thienyl]-4-Methyl-N-cis-1-Oxaspiro[2.5]Oct-6-Yl-, (1R)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and alkyne-substituted thiophene structure. This compound is of significant value for enabling sophisticated synthetic routes in medicinal chemistry, particularly for the development of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and process development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in research targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique spiro[2.5]octane and alkyne functionalities.
• Process Chemistry Development: Serves as a critical intermediate for scaling up the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: The alkyne group can be utilized in click chemistry applications for labeling and studying biological pathways.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Used in university laboratories for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-Cyclohexene-1-Carboxamide, N-[5-(3,3-Dimethyl-1-Butyn-1-Yl)-3-Thienyl]-4-Methyl-N-cis-1-Oxaspiro[2.5]Oct-6-Yl-, (1R)-
CAS No.	1562406-69-2
Molecular Formula	C24H31NO2S
Molecular Weight	397.57 g/mol
Synonyms	(1R)-N-[5-(3,3-Dimethylbut-1-yn-1-yl)-3-thienyl]-4-methyl-N-[(1S,5R,6R)-6-methyl-1-oxaspiro[2.5]oct-5-yl]-3-cyclohexene-1-carboxamide; (1R)-cis-N-[5-(3,3-Dimethyl-1-butyn-1-yl)-3-thienyl]-4-methyl-N-(6-methyl-1-oxaspiro[2.5]oct-5-yl)-3-cyclohexene-1-carboxamide; 1562406-69-2; UNII-9F6C8Q4V4P; 9F6C8Q4V4P; Spirocyclic Carboxamide Intermediate; Alkyne-Thiophene Spiro Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity, critical for pharmaceutical research. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development under quality agreements and can align with ICH guidelines for impurity identification and control.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.