Description

Banoxantrone (D12 Dihydrochloride) is a deuterated analog of the anthracenedione-based antineoplastic agent, Ametantrone. This compound is a critical tool in pharmaceutical research, particularly for use as an internal standard in quantitative bioanalytical methods such as LC-MS/MS, ensuring accurate pharmacokinetic and metabolic studies. It is essential for researchers and developers in the fields of oncology drug development, analytical chemistry, and stable isotope labeling, where precise measurement and high chemical purity are paramount.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a deuterated internal standard for the accurate quantification of Ametantrone and related compounds in biological matrices (plasma, serum, tissue homogenates).
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Oncology Research: Used in the development and validation of analytical methods for anthracenedione-based chemotherapeutic agents.
• Stable Isotope Labeling: Serves as a reference material in studies utilizing deuterium labeling to investigate metabolic pathways or chemical stability.
• Quality Control in Pharmaceutical Manufacturing: Supports method development and validation for the impurity profiling and assay of active pharmaceutical ingredients (APIs).
• Reference Standard: Provides a certified reference material for calibrating analytical instruments and ensuring regulatory compliance in laboratory testing.

Basic Information

Product Name	Banoxantrone (D12 Dihydrochloride)
CAS No.	1562066-98-1
Molecular Formula	C₂₂H₁₈D₁₂N₄O₆ • 2HCl
Molecular Weight	Contact for details
Synonyms	1,4-Bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione (D12) Dihydrochloride; Ametantrone D12 Dihydrochloride; 1,4-Bis({2-[(2-hydroxyethyl)amino]ethyl})amino)anthracene-9,10-dione (D12) Dihydrochloride; NSC-287513 D12; Banoxantrone-d12 Dihydrochloride; Deuterated Ametantrone Dihydrochloride
EINECS	Contact for details

Quality Control

Our Banoxantrone (D12 Dihydrochloride) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the high standards required for research and development. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.