Description

4-Fluoro-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is crucial for medicinal chemistry research and development, serving as a key intermediate in the synthesis of novel pharmaceutical candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to introduce complex indazole-based scaffolds into target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space.
• Agrochemical Development: Serves as a precursor in the creation of novel active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.
• Library Synthesis: Enables the creation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	4-Fluoro-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	1561772-33-5
Molecular Formula	C₁₂H₁₂FIN₂O
Molecular Weight	346.14 g/mol
Synonyms	4-Fluoro-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1-(Oxan-2-yl)-4-fluoro-3-iodo-indazole; 4-Fluoro-3-iodo-1-(tetrahydropyran-2-yl)-1H-indazole; 4-Fluoro-3-iodo-1-(THP)-1H-indazole; 4-Fluoro-3-iodo-1-(2-tetrahydropyranyl)-1H-indazole; 1H-Indazole, 4-fluoro-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-; THP-protected 4-fluoro-3-iodoindazole
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.