Description

2-[(1R,2R)-1,2-Diphenyl-2-(Piperidin-1-Yl)Ethyl]-2,3-Dihydro-1H-Isoindole-1,3-Dione is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its complex stereochemistry and functional groups, which make it a critical precursor in the synthesis of advanced active pharmaceutical ingredients (APIs). This compound is essential for research and development organizations and manufacturers in the pharmaceutical and fine chemical sectors seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and other therapeutic areas.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective organic synthesis to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold or intermediate for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for target molecules requiring high enantiomeric purity.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Catalyst or Ligand Precursor: Potential use in the development of chiral catalysts or ligands for catalytic asymmetric transformations.

Basic Information

Product Name	2-[(1R,2R)-1,2-Diphenyl-2-(Piperidin-1-Yl)Ethyl]-2,3-Dihydro-1H-Isoindole-1,3-Dione
CAS No.	1558718-40-3
Molecular Formula	C33H30N2O2
Molecular Weight	486.61 g/mol
Synonyms	(1R,2R)-1,2-Diphenyl-2-(piperidin-1-yl)ethyl phthalimide; (1R,2R)-N-[1,2-Diphenyl-2-(piperidin-1-yl)ethyl]phthalimide; (1R,2R)-1,2-Diphenyl-2-(1-piperidinyl)ethyl-1H-isoindole-1,3(2H)-dione; (1R,2R)-1,2-Diphenyl-2-(piperidin-1-yl)ethyl-1H-isoindole-1,3(2H)-dione; (1R,2R)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,2-diphenyl-1-(piperidin-1-yl)ethane
EINECS	Contact for details

Quality Control

Our 2-[(1R,2R)-1,2-Diphenyl-2-(Piperidin-1-Yl)Ethyl]-2,3-Dihydro-1H-Isoindole-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.