Description

2-Bromo-4-(Difluoromethyl)Thiazole is a high-value halogenated heterocyclic building block, specifically engineered for advanced synthetic chemistry. Its core value lies in its unique molecular architecture, which combines a reactive bromine atom with a difluoromethyl-substituted thiazole ring, enabling precise structural modifications in target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Active Ingredient Development: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole core.
• Material Science Research: Serves as a precursor for functionalized molecules used in organic electronics, such as OLED materials and conductive polymers.
• Chemical Biology & Proteomics: Employed as a versatile labeling agent or a building block for activity-based probes to study enzyme function and protein interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings for carbon-carbon bond formation.
• Fluorine Chemistry: The difluoromethyl group is a valuable isostere, used to modulate the lipophilicity, metabolic stability, and bioavailability of lead compounds.

Basic Information

Product Name	2-Bromo-4-(Difluoromethyl)Thiazole
CAS No.	1545252-82-1
Molecular Formula	C4H2BrF2NS
Molecular Weight	210.03 g/mol
Synonyms	4-(Difluoromethyl)-2-bromothiazole; 2-Bromo-4-difluoromethylthiazole; Thiazole, 2-bromo-4-(difluoromethyl)-; 1545252-82-1; 2-Bromo-4-(difluoromethyl)-1,3-thiazole; 2-Bromo-4-(difluoromethyl)thiazole; 4-(Difluoromethyl)-2-bromo-1,3-thiazole
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Difluoromethyl)Thiazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.