Description

4-Amino-2-Hydroxy-Bicyclo[2.2.2]Octane-1-Methanol is a highly functionalized bicyclic organic compound that serves as a sophisticated chiral building block in advanced organic synthesis. Its unique rigid scaffold, combined with amino, hydroxy, and methanol functional groups, makes it a valuable intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is particularly sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry, asymmetric catalysis, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Catalysis: Used as a precursor for designing and synthesizing novel chiral ligands and organocatalysts.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products, agrochemicals, and specialty chemicals requiring a rigid, functionalized bicyclic core.
• Academic & Industrial Research: Serves as a valuable reference standard and starting material in chemical research exploring new reaction methodologies and structure-activity relationships (SAR).
• Material Science Precursor: Potential use in the synthesis of advanced organic frameworks and polymers with specific structural properties.

Basic Information

Item	Details
Product Name	4-Amino-2-Hydroxy-Bicyclo[2.2.2]Octane-1-Methanol
CAS No.	1544662-64-7
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	1-(Aminomethyl)bicyclo[2.2.2]octan-2-ol; 2-Hydroxybicyclo[2.2.2]octane-1-methanamine; 4-Amino-2-hydroxybicyclo[2.2.2]octane-1-methanol; Bicyclo[2.2.2]octane-1-methanol, 4-amino-2-hydroxy-; (1R,2S,4S)-4-Amino-2-hydroxybicyclo[2.2.2]octane-1-methanol (for specific stereoisomers)
EINECS	Contact for details

Quality Control

Our production of 4-Amino-2-Hydroxy-Bicyclo[2.2.2]Octane-1-Methanol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.