Description

4-Amino-2-Hydroxy-Bicyclo[2.2.2]Octane-1-Carboxylic Acid Ethyl Ester is a specialized bicyclic amino acid derivative with a constrained, rigid molecular architecture. This compound matters as a high-value pharmaceutical intermediate and chiral building block for the synthesis of complex molecules, offering unique stereochemical control. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used as a building block for creating novel, high-performance pesticides and herbicides with specific stereochemical requirements.
• Asymmetric Catalysis: Serves as a precursor or ligand for chiral catalysts used in enantioselective synthesis.
• Peptidomimetics & Bioactive Molecule Design: Its constrained bicyclic structure is valuable for designing peptide analogs and other bioactive compounds with enhanced stability and receptor selectivity.
• Academic & Industrial Research: A valuable tool compound in medicinal chemistry and organic synthesis research for exploring new chemical space.
• Advanced Material Precursor: Potential use in the synthesis of specialty polymers or functional materials requiring rigid, amino-functionalized components.

Basic Information

Item	Detail
Product Name	4-Amino-2-Hydroxy-Bicyclo[2.2.2]Octane-1-Carboxylic Acid Ethyl Ester
CAS No.	1544662-59-0
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	Ethyl 4-Amino-2-hydroxybicyclo[2.2.2]octane-1-carboxylate; 4-Amino-2-hydroxybicyclo[2.2.2]octane-1-carboxylic acid ethyl ester; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-amino-2-hydroxy-, ethyl ester; 1-Carbethoxy-4-amino-2-hydroxybicyclo[2.2.2]octane
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Hydroxy-Bicyclo[2.2.2]Octane-1-Carboxylic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with full characterization data are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.